What are Th1 and Th2
What are Th1 and Th2?
When we run the Full Body Biofeedback Analyses in the Tuscon. Humoral Immunity aka Th2 and Cell-Mediated Immunity aka Th1 come up often, even in cases where no autoimmune diagnosis has been made. Why is this? Well, we are about to go into what these 2 things mean and what you can do about it. The #1 underlying cause that is nearly impossible to test for, and will always be blocked by cortisol is “Histamine Intolerance and Histamine Related Issues”. We go into this deeper throughout our website here. There has not been any case or chronic condition that did not have an issue with Histamine Reactions in the body.
Chronic Health Conditions in Tuscon
Nearly every chronic health condition has a 3 step activation process:
- Trauma, Injury, Overwhelm: This can be a car accident, pregnancy, vaccinations, emotional trauma (break up, loss of a loved one or pet, etc), unprocessed emotions, chronic recurring stress, genes that we’ve activated via lifestyle/emotional/dietary exposures, etc. This is the Trigger, and sometimes it goes unnoticed for years or decades as it just appears to be “aging, lower energy and other malfunctions of our systems.
- Histamine Cascade: Our immune system goes into overdrive to address the point of injury or overwhelm creating a perpetual inflammatory waterfall in our cells, tissues, organs, and brain. Over time this continues to wear down and destroy our organ functions, cellular health, diminishes cell voltage, reduces our ATP production, etc.
- Paralysis: In our center, we deal with chronic conditions, so paralysis, in this case, means the body has become stuck in a time loop unable to move beyond the trigger point into healing. We call this feedback loops. Our cells, brain and tissues are stuck at the point of trigger(s) and the loop continues to compromise and wear down our health the longer it goes unaddressed. There are things that herbs and nutrition just can’t address, this is why Frequency Medicine is so crucial and is dramatically changing the face of medicine. Not only, does it break the loops it actually resets the functionality of whatever is being treated and even has been shown to regenerate tissues.
There is much deeper scientific info in regards to this but this is why so many people have food, nutrient, and other life sensitivities as their Histamine responses are chronically “on” in varying degrees.
How do you clear paralysis from a system?
The fastest way is frequencies: Biofeedback, Neurofeedback and Frequency Therapies. This cuts healing and recovery from years into weeks and months because of the precision of communication and application. The Future of Medicine spoken about 100 years ago is now here ✨
“Frequency Therapy is the cutting edge of Medicine. It’s precisely because it pinpoints the cause of an ailment, no matter how complex and treats it without side effects.”
- Dr. James L. Oschman, PhD
What are the Th1 and Th2?
Those that suffer from an autoimmune disease commonly experience symptoms that stem from imbalances within the functioning of their immune system. There are many factors that can influence this balance - stress, nutrition, vitamin and mineral deficiencies, gut flora, and allergies, among others. This way of looking at autoimmune disease is a growing trend in the alternative field, highlighted through the work of Datis Kharrazian.
T-helper cells (abbreviated as Th) are a vital part of the immune system. They are lymphocytes (types of white blood cells) that recognize foreign pathogens or in the case of autoimmune disease, normal tissue. In response to this recognition, they produce cytokines, which are hormonal messenger proteins that are responsible for the biological effects of the immune system. They are divided into subgroups as follows:
- Th1: Th1 cells are involved in what is called “cell-mediated” immunity, which usually deals with infections by viruses and certain bacteria. They are the body’s first line of defense against pathogens that get inside our cells. They tend to be pro-inflammatory and are involved in the development of the organ-specific autoimmune disease.
- Th2: Th2 cells are involved in what is called “humoral-mediated” immunity, which deals with bacteria, toxins, and allergens. They are responsible for stimulating the production of antibodies in response to extracellular pathogens (those found in blood or other body fluids). They tend not to be inflammatory and are involved in systemic autoimmune disease and other chronic conditions.
In a well-functioning immune system, both groups of these T-helper cells work together to keep the system balanced. One side might become more active to eradicate a threat, then settling back to a balanced level.
How Does this affect autoimmune disease?
In some people with autoimmune disease, patterns showing dominance to either the Th1 or Th2 pathway have been shown. Although there are exceptions, the following table shows the conditions that are most commonly associated with a Th1 or Th2 dominant state:
TH1 dominant conditions:
- Type I diabetes
- Multiple sclerosis
- Hashimoto’s Thyroiditis
- Grave’s Disease
- Crohn’s Disease
- Sjoren’s Syndrome
- Celiac Disease
- Lichen Planus
- Rheumatoid Arthritis
- Chronic viral infections
TH2 dominant conditions:
- Allergic Dermatitis
- Atopic Eczema
- Inflammatory Bowel Disease
- Ulcerative Colitis
- Multiple chemical sensitivity
When the Th1 cells of the immune system are overactive, they can suppress the activity of Th2 and vice versa. This can be problematic because of these two components of the immune system function in a delicately balanced relationship. In the case of autoimmune disease, the imbalance can further the attack on healthy tissue, thereby worsening symptoms.
Although research can lump those with certain conditions under the Th1/2 categories, in reality, they can be all over the map. For instance, although most of Hashimoto’s patients present a Th1 dominance, some can be Th2. It is also possible to have both Th1 and Th2 simultaneously overactive or under-active.
Pregnancy can shift the immune system temporarily to Th2, which is why a lot of women find out they have Hashimoto’s after they give birth and their immune system returns to Th1 dominance.
How do I find out if I am Th1 or Th2 dominant?
There is a Th1/Th2 cytokine blood panel that your doctor can order to find out if your immune system is imbalanced. You can also do a challenge with certain nutritional compounds that stimulate either Th1 or Th2, although this can be tricky and is best done under the supervision of a practitioner.
What is the protocol for balancing the immune system?
Dr. Kharrazian is the practitioner who has developed the protocol for treating autoimmune disease by balancing Th1 and Th2. If Th1 is dominant, he will use Th2 stimulating compounds to raise the level of Th2, and vice versa.
In addition, he uses other vitamins and compounds that are known to modulate the balance between Th1 and Th2. His view is that by balancing Th1 and Th2, the autoimmune attack is lessened and the body is able to function closer to normal. He also places his patients on an autoimmune gut-repair diet.
Many people have been helped by using this protocol for the treatment of Hashimoto’s disease. That being said, balancing the immune system for those with autoimmune disease is still tricky business and baffles even the most skilled practitioners. There are many people who have had a negative experience using this type of treatment, most likely because it is easy to accidentally stimulate their dominant pathway, causing the autoimmune attack to worsen. The Th1/Th2 stimulating compounds are as follows:
Th1 Stimulating Compounds:
- Medicinal Mushrooms (Maitake and Beta-Glucan are common)
- Glycyrrhiza (found in licorice)
- Melissa Oficinalis (Lemon balm)
- Panax Ginseng
- Grape Seed Extract
Th2 Stimulating Compounds
- Green Tea Extract
- Pine Bark Extract
- White Willow Bark
- Lycopene (found in tomatoes and other red fruits excluding strawberries and cherries)
- Resveratrol (found in grape skin, sprouted peanuts, and cocoa)
- Pycnogenol (found in the extract of the French maritime pine bark and apples)
- Curcumin (found in turmeric)
- Genistin (found in soybeans)
- Quercitin (a flavanoid found in many fruits and vegetables, such as onions, berries and kale)
Why is it important to know about these compounds?
As you can see, many items on the list are common and are used by many people on a regular basis. Echinacea, for example, is a common herbal cold and flu remedy, but it can cause someone with a Th1 dominant condition to worsen. Likewise, a person with a Th2 dominant condition that is drinking a few cups of coffee everyday could be unintentionally stimulating the already dominant Th2 pathway. The opposite could be true - a Th1 dominant person may benefit from the consumption of caffeine, although this gets a little messy when you add a person’s adrenal status to the mix (caffeine may help them if they have low cortisol, but they could still be Th2 dominant and have worsening autoimmune symptoms from it).
If you suffer from an autoimmune disease, chances are you are going to be sensitive to supplements that effect the immune system. Just knowing how powerful these compounds are is useful information even if you are not going to attempt to use them to balance your levels of Th1 and Th2.
Is there a safer way to balance Th1 and Th2?
Playing with the balance of Th1 and Th2 is tricky and some people do not do well with it, even under the care of a practitioner. Using vitamins and nutrients that naturally modulate the balance between Th1 and Th2 or support T-regulatory cell function is much less risky than taking supplements that directly stimulate either one. The following compounds have been shown in studies to do this:
TH1 and TH2 modulating compounds:
- Probiotics (found in fermented foods like kimchi, saurkraut, yogurt, kombucha, kefir, as well as supplements)
- Vitamin A (found in liver and cod liver oil as well as butter and eggs from pastured animals)
- Vitamin E (found in red palm oil, pastured egg yolks, avocados, as well as nuts and seeds)
- Colostrom (a mother’s first milk that is available in supplement form)
T-regulatory supporting compounds:
- Vitamin D (obtained by sunbathing, also found in liver, cod liver oil, sardines, raw dairy and pastured eggs)
- EPA and DHA (found in fatty cold-water fish such as salmon, sardines and mackerel as well as in pastured meats and eggs in smaller quantities)
In conclusion, I believe that it is good for autoimmune patients to know which compounds stimulate Th1 and Th2 because of how they can better or worsen the progression of the disease. Knowing one’s Th1 or Th2 dominance and treating with supplements to achieve balance can be helpful to some, but I don’t believe that is the best and safest approach for everyone.
If you do decide to go this route, make sure to enlist the help of a practitioner who is skilled at using this treatment for autoimmune disease. A safer alternative is to focus on compounds that have been shown to modulate the immune system, in addition to implementing other strategies that have been shown to help autoimmune disease.
What can you do about it? Book an initial session with us here – then we have multiple ways to address all the above listed challenges, and even have Frequency Specific Treatments for Th1 and Th2 malfunctions. *This post was originally created for The Paleo Mom and re-posted here at www.TucsonBiofeedback.com.
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